Fecha/hora: 01/06/2024 04:03:20

Biblioteca(s): | INIA Treinta y Tres.
Tipo de la producción científica: | Artículos en Revistas Indexadas Internacionales
Circulación/Nivel: | A - A
Fecha corriente: | 17/04/2017
Fecha de la última actualización: | 11/10/2019
Autoria: | LAKIN, S.M.; DEAN, C.; NOYES, N.R.; DETTENWANGER, A.; ROSS, A. S.; DOSTER, E.; ROVIRA, P.J.; ABDO, Z.; JONES, K.L.; RUIZ, J.; BELK, K.E.; MORLEY, P.S.; BOUCHER, C.
Afiliación: | STEVEN M. LAKIN; CHRIS DEAN; NOELLE R. NOYES; ADAM DETTENWANGER; ANNE SPENCER ROSS; ENRIQUE DOSTER; PABLO JUAN ROVIRA SANZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. Department of Animal Sciences, Colorado State University, USA.; ZAID ABDO; KENNETH L. JONES; JAIME RUIZ; KEITH E. BELK; PAUL S. MORLEY; CHRISTINA BOUCHER.
Título: | MEGARes: an antimicrobial resistance database for high throughput sequencing.
Año de publicación: | 2017
Fuente/Imprenta: | Nucleic Acids Research, 2017 v.45 p.574-580.
DOI: | 10.1093/nar/gkw1009
Idioma: | Inglés

Notas:

Article History: Published online 2016 Nov 24.
DOI: https://doi.org/10.1093/nar/gkw1009

Contenido: | Antimicrobial resistance has become an imminent concern for public health. As methods for detection and characterization of antimicrobial resistance move from targeted culture and polymerase chain reaction to high throughput metagenomics, appropriate resources for the analysis of large-scale data are required. Currently, antimicrobial resistance databases are tailored to smaller-scale, functional profiling of genes using highly descriptive annotations. Such characteristics do not facilitate the analysis of large-scale, ecological sequence datasets such as those produced with the use of metagenomics for surveillance. In order to overcome these limitations, we present MEGARes (https://megares.meglab.org), a hand-curated antimicrobial resistance database and annotation structure that provides a foundation for the development of high throughput acyclical classifiers and hierarchical statistical analysis of big data. MEGARes can be browsed as a stand-alone resource through the website or can be easily integrated into sequence analysis pipelines through download. Also via the website, we provide documentation for AmrPlusPlus, a user-friendly Galaxy pipeline for the analysis of high throughput sequencing data that is pre-packaged for use with the MEGARes database.
Palabras-Clave: | BASE DE DATOS; BIOINFORMÁTICA; DATASETS; DRUG RESISTANCE; GENES; METAGENÓMICA; METAGENOMICS; MICROBIAL; POLYMERASE CHAIN REACTION; PUBLIC HEALTH MEDICINE; RESISTENCIA ANTIMICROBIANA; SEQUENCE ANALYSIS.
Categoría del tema: | L01 Ganadería

URL:

http://www.ainfo.inia.uy/digital/bitstream/item/6677/1/Rovira-arb-2017-1.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210519/

Registro original: | INIA Treinta y Tres (TT)
Ejemplares: | TT - (102015-1) - PXI - AP - DD - PP/NUCLEIC-ACIDS-RESEARCH/2017/45/1 -  -  - DIS